Piperazine → 7-bromo-2-chloro-4-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole

Participants

Reaction Steps

1.3 g (4.10 mmol) 7-bromo-2,4-dichloro-5H-pyrimido[5,4-b]indole (Example 4) and 1.3 g (14.8 mmol) piperazine were heated in 50 ml toluene at 65° C. for 3 h. Then, the solvent was removed and the residue was suspended in water and sucked off. 1.3 g (87%) 7-bromo-2-chloro-4-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole was obtained. ESI-MS [m/z]: 366, 368 [M+H]+

Provenance & Evidence