Potassium Phosphate, Tribasic → CD-160130

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine	HCID 2734648	—
Reactant	2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl	HCID 11269872	—
Reactant	HCID 66863934	HCID 66863934	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	Water	HCID 962	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	CD-160130	HCID 24990553	—

Reaction Steps

150 mg (0.4 mmol) 7-bromo-4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole (Example 4), 123 mg (0.6 mmol) 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 276 mg (1.2 mmol) K3PO4×H2O, 6.6 mg (16 mmol) S-Phos and 9.2 mg (8 mmol) Pd(PPh3)4 in 6 ml THF were heated in a microwave oven to 120° C. for 2 h. Then, the solvent was removed and following LC (CH2Cl2/MeOH, O-20%) 93 mg (62%) of the title substance was obtained ESI-MS [m/z]: 375 [M+H]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08664233B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-6ab0826f7835467ab3b76b3f1bf9d36d
Source note	uspto-grants-2014_03