Potassium Carbonate → HCID 66864166, compound

Participants

Reaction Conditions

Reaction Steps

10.0 g (50.0 mmol) 3-bromo-2-fluorobenzonitrile, 11.1 g (100.0 mmol) glycinamide hydrochloride and 17.3 g (125 mmol) K2CO3 were suspended in 90 ml DMSO and heated at 100° C. for 4 h. Having cooled down to room temperature, the solvent was concentrated and water was added. The resulting precipitate was sucked off and washed with water. 10.8 g (85%) 2-(2-bromo-6-cyano-phenylamino)acetamide was obtained. ESI-MS [m/z]: 254, 256 [M+H]+

Provenance & Evidence