HuagongsheHuagongshe Chemistry Print Report · For research reference only
3(R)-Pyrrolidinyloxyamine dihydrochloride → (3E,5S,6S,8S,9S,10R,13S,14S,17S)-4,4,10,13-tetramethyl-3-[(3R)-pyrrolidin-3-yl]oxyimino-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-5,6,17-triol;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3(R)-Pyrrolidinyloxyamine dihydrochloride | HCID 66713918 | — |
| Reactant | 5alpha,6alpha,17beta-Trihydroxy-4,4-dimethylandrostan-3-one | HCID 68732243 | — |
| Product | (3E,5S,6S,8S,9S,10R,13S,14S,17S)-4,4,10,13-tetramethyl-3-[(3R)-pyrrolidin-3-yl]oxyimino-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-5,6,17-triol;hydrochloride | HCID 87553883 | 90% |
Reaction Steps
The title compound was prepared in 90% yield (121 mg) as described in Example 2 starting from 5α,6α,17β-trihydroxy-4,4-dimethylandrostan-3-one, (Preparation 5, 100 mg) and 3-(R)-pyrrolidinyloxyamine dihydrochloride (Preparation 12, 200 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664210B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-eacc3f39bcc14f6dbdbc1a1ac219f630 |
| Source note | uspto-grants-2014_03 |