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HRID1182861

反应详情

EQUATION

反应方程式

HRID 1182861 的结构方程式

REACTANTS

反应物

2
结构：Cl.Cl.NCCON
HCID14362326

2-(Aminooxy)ethan-1-amine--hydrogen chloride (1/2)

C2H10Cl2N2O

结构：CC1(C)C(=O)CC[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3C[C@@H]3O[C@]312
HCID86649177

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)/C(=N/OCCN)CC[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3C[C@@H]3O[C@]312.Cl
HCID87552587

未命名化合物

收率 68%

PROCEDURE

实验过程

The title compound was prepared as described in Example 2 starting from 5α,6α-epoxy-17β-hydroxy-4,4-dimethylandrostan-3-one, (Preparation 8, 54 mg) and 2-aminoethoxyamine dihydrochloride (97 mg). The solution was evaporated, water was added and the aqueous phase was extracted with THF. The combined organic extracts were washed with brine, dried over Na2SO4 and evaporated to dryness. The crude product was triturated with diisopropyl ether/MeOH 95/5 and the precipitate was filtered to give the title compound (47 mg, 68%).

WORKUP

后处理

  1. customThe title compound was prepared
  2. customThe solution was evaporated
  3. additionwater was added
  4. extractionthe aqueous phase was extracted with THF
  5. washThe combined organic extracts were washed with brine
  6. dry with materialdried over Na2SO4
  7. customevaporated to dryness
  8. customThe crude product was triturated with diisopropyl ether/MeOH 95/5
  9. filtrationthe precipitate was filtered