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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1182862Generated: November 3, 2026

3(R)-Pyrrolidinyloxyamine dihydrochloride → (1S,2R,5E,7S,9S,11S,12S,15S,16S)-2,6,6,16-tetramethyl-5-[(3R)-pyrrolidin-3-yl]oxyimino-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-15-ol;hydrochloride

https://huagongshe.com/reaction/1182862

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3(R)-Pyrrolidinyloxyamine dihydrochlorideHCID 66713918—
Reactant5alpha,6alpha-Epoxy-17beta-hydroxy-4,4-dimethylandrostan-3-oneHCID 86649177—
Product(1S,2R,5E,7S,9S,11S,12S,15S,16S)-2,6,6,16-tetramethyl-5-[(3R)-pyrrolidin-3-yl]oxyimino-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-15-ol;hydrochlorideHCID 8757266775%

Reaction Steps

Prepared in 75% yield (51 mg) as described in Example 2 starting from 5α,6α-epoxy-17β-hydroxy-4,4-dimethylandrostan-3-one, (Preparation 8, 50 mg) and 3-(R)-pyrrolidinyloxyamine dihydrochloride (Preparation 12, 105 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08664210B2
Source datasetuspto-grants-2014_03
ORD IDord-6441a0eda6274083a4174e29638a54cd
Source noteuspto-grants-2014_03