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HRID1182867

反应详情

EQUATION

反应方程式

HRID 1182867 的结构方程式

REACTANTS

反应物

2
结构：CON.Cl
HCID521874

O-Methylhydroxylamine hydrochloride

CH6ClNO

结构：C[C@]12CC[C@H]3[C@@H](CC(=O)C4C/C(=N\O[C@@H]5CCNC5)[C@H](F)C[C@@]43C)[C@@H]1CC[C@@H]2O.O=C(O)/C=C/C(=O)O
HCID87552262

未命名化合物

PRODUCTS

生成物

1
结构：CO/N=C1\C[C@H]2[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]2[C@@]2(C)C[C@@H](F)/C(=N/O[C@@H]3CCNC3)CC12.O=C(O)/C=C/C(=O)O
HCID178502616

未命名化合物

PROCEDURE

实验过程

The title compound was obtained in 56% yield following the procedure described in Example 34 starting from (E)-3-[3-(R)-pyrrolidinyl]oxyimino-2α-fluoro-17β-hydroxyandrostan-6-one fumarate (Example 35, 72 mg) and methoxyamine hydrochloride (14 mg). After evaporation of the solvent the crude reaction mixture was purified by flash chromatography (SiO2, CHCl3/MeOH/26% NH4OH 90/10/1). To the concentrated fractions, a stoichiometric amount of fumaric acid in MeOH was added. The resulting precipitate was rinsed with heptane and filtered to give the title compound I-bk.

WORKUP

后处理

  1. customAfter evaporation of the solvent the crude
  2. customreaction mixture
  3. customwas purified by flash chromatography (SiO2, CHCl3/MeOH/26% NH4OH 90/10/1)
  4. additionTo the concentrated fractions, a stoichiometric amount of fumaric acid in MeOH was added
  5. washThe resulting precipitate was rinsed with heptane
  6. filtrationfiltered