Water → HCID 87553220, compound

Participants

Reaction Steps

To a stirred solution of a mixture of (E)-3-(2-aminoethoxyimino)-4,4-dimethylandrost-5-en-17β-ol (Example 2, 250 mg) and Et3N (0.14 ml) under N2 in DCM (10 ml) at 0° C., 9-fluorenylmethoxycarbonyl chloride (170 mg) was added. After stirring at RT for 15 minutes, water was added and the mixture was extracted with DCM. The organic phase was washed with 5% NaHCO3 dried over Na2SO4 and evaporated to dryness to give 3-(E)-{2-[N-(9-fluorenylmethoxy-carbonyl)]aminoethoxyimino}-4,4-dimethylandrost-5-en-17β-ol (392 mg, 99%).

Provenance & Evidence