HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4,4-Dimethyl-17beta-tert-butyldimethylsilyloxyandrost-5-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 17beta-Hydroxy-4,4-dimethylandrost-5-en-3-one | HCID 224156 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4,4-Dimethyl-17beta-tert-butyldimethylsilyloxyandrost-5-en-3-one | HCID 68729117 | 93% |
Reaction Steps
To a suspension of 4,4-dimethyl-17β-hydroxyandrost-5-en-3-one (3.34 g) in DMF (30 ml), imidazole (1.40 g) and tert-butyldimethylsilyl chloride (3.15 g) were added. After stirring the mixture overnight at RT, water was added, and stirring was continued for 30 min at 0° C. The formed solid was filtered and, after drying, 4,4-dimethyl-17β-tert-butyldimethylsilyloxyandrost-5-en-3-one was obtained (4.0 g, 93% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664210B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-16094f7580d44b2e9ebdb586b50780bf |
| Source note | uspto-grants-2014_03 |