HCID 131731232, compound → HCID 131731231, compound

Participants

Reaction Steps

To a solution of 3,3-(ethylenedioxy)-4,4-dimethyl-17β-tert-butyldimethyl-silyloxyandrost-5-en-7-one (3.9 g) in dioxane (270 ml), Pd/C 10% (390 mg) was added, and then the mixture was hydrogenated at RT for 72 h. The catalyst was filtered off, washed with EtOAc and the organic phase evaporated under reduced pressure. The crude reaction mixture was purified by flash chromatography (SiO2, n-hexane/EtOAc/toluene 90/5/5) to give 3,3-(ethylenedioxy)-4,4-dimethyl-17β-tert-butyldimethyl-silyloxyandrostan-7-one (2.44 g, 63% yield).

Provenance & Evidence