HCID 68729052, compound → HCID 68733445, compound

Participants

Reaction Steps

To a solution of 2α-fluoro-6-methoxy-17β-hydroxyandrosta-4,6-dien-3-one (610 mg) in THF (10 ml), 3N HCl (2 ml) was added and the mixture refluxed for 1 h. After cooling, Na2HPO4 5% was added and the reaction mixture was extracted with EtOAc. The organic phase was washed with H2O and brine, dried over Na2SO4 and evaporated to dryness. The crude reaction mixture was purified by flash chromatography (SiO2, n-hexane/DCM/acetone 5/3/2) to give 2α-fluoro-17β-hydroxyandrost-4-en-3,6-dione (590 mg, 84% yield).

Provenance & Evidence