Hydrochloric Acid → HCID 68732160, compound

Participants

Reaction Steps

To a solution of 2α-fluoro-17β-hydroxyandrost-4-en-3,6-dione (510 mg) in acetone (76 ml), NaI (950 mg) and conc. HCl (0.51 ml) were added. The mixture was then stirred at RT for 5 min. NaHCO3 was added until neutrality. The organic layer was diluted with Et2O and washed with Na2S2O3 till the brown colour disappeared. The organic phase was washed with H2O and brine, dried over Na2SO4 and was evaporated to dryness. The crude reaction mixture was purified by flash chromatography (SiO2, n-hexane/DCM/acetone 5/3/2) to give the title compound in 72% yield.

Provenance & Evidence