反应详情

15.5 g (57 mmol) of tert-butyl {6-chloro-3-[(hydroxyimino)methyl]pyridin-2-yl}carbamate (Example 3A) were dissolved in 285 ml of 4 N hydrogen chloride in dioxane and stirred for a further 30 min. The reaction mixture was concentrated by half and the same amount of diethyl ether was added. The reaction mixture was stirred for a further 20 min and the product was filtered off and washed with diethyl ether. 11 g (94% of theory) of the product were obtained in solid form.

1. concentrationThe reaction mixture was concentrated by half
2. additionthe same amount of diethyl ether was added
3. stirringThe reaction mixture was stirred for a further 20 min
4. filtrationthe product was filtered off
5. washwashed with diethyl ether
6. custom11 g (94% of theory) of the product were obtained in solid form