Pyridine → 2-Amino-6-chloropyridine-3-carbonitrile

関与物質

反応条件

反応手順

11.15 g (53.6 mmol) of 2-amino-6-chloropyridine-3-carbaldehyde oxime hydrochloride (Example 4A) were initially charged in dioxane, admixed with 13 ml (161 mmol) of pyridine and cooled to 0° C. 8.3 ml (58.95 mmol) of trifluoroacetic anhydride were added, and the reaction was warmed to RT and then stirred at 60° C. for 2 h. The reaction mixture was taken up in a mixture of ethyl acetate and sodium hydrogencarbonate solution. The organic phase was washed with saturated aqueous sodium chloride solution, dried over magnesium sulphate and concentrated on a rotary evaporator. The residue was suspended in 3:1 dichloromethane:diethyl ether, and the solids were filtered off with suction and dried. 5.56 g (66% of theory) of the product were obtained in solid form.

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