反应详情

2.00 g (6.3 mmol) of tert-butyl 3-[(6-amino-5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate (Example 9A) were dissolved in 40 ml of a hydrochloric acid solution in dioxane (4 M) and stirred at RT for 2 h. On completion of reaction, the solvent was concentrated by half, and 20 ml of diethyl ether were added. The precipitate was filtered off and dried. 1.80 g (100% of theory) of the product were obtained in solid form.

1. customOn completion of reaction
2. concentrationthe solvent was concentrated by half, and 20 ml of diethyl ether
3. additionwere added
4. filtrationThe precipitate was filtered off
5. customdried
6. custom1.80 g (100% of theory) of the product were obtained in solid form