Hydrochloric Acid → 1-[2-Amino-6-(piperidin-3-ylamino)pyridin-3-yl]-2,2,2-trifluoroethanone hydrochloride

Participants

Reaction Steps

670 mg (1.37 mmol) of tert-butyl 3-({6-[(tert-butoxycarbonyl)amino]-5-(trifluoroacetyl)pyridin-2-yl}amino)piperidine-1-carboxylate (Example 12A) were dissolved in 25 ml of a hydrochloric acid solution in dioxane (4 M) and stirred at RT for 20 h. On completion of reaction, the reaction mixture was diluted with diethyl ether (100 ml), and the precipitate was filtered off completely and washed with diethyl ether (100 ml) and dried. 286 mg (64% of theory) of the product were obtained in solid form.

Provenance & Evidence