Methyl 2-chloro-6-(2-methoxyphenyl)pyridine-3-carboxylate → Methyl 2-(3-{[6-amino-5-(trifluoroacetyl)pyridin-2-yl]amino}piperidin-1-yl)-6-(2-methoxyphenyl)pyridine-3-carboxylate hydrochloride

Participants

Reaction Steps

Analogously to the preparation of Example 8, 255 mg (0.84 mmol) of methyl 2-chloro-6-(2-methoxyphenyl)pyridine-3-carboxylate (Example 17A) and 299 mg (0.92 mmol) of 1-[2-amino-6-(piperidin-3-ylamino)pyridin-3-yl]-2,2,2-trifluoroethanone hydrochloride (Example 13A) were used to obtain, after purification of the crude product by means of preparative HPLC (method 10), 275 mg (58% of theory) of the product in solid form.

Provenance & Evidence