6-(Piperidin-3-ylamino)nicotinonitrile hydrochloride → HCID 67331684, compound

HRID 1183013Notes

Reaction equation

HRID 1183013 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:4]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[N:3]=1.Cl.[NH:22]1[CH2:27][CH2:26][CH2:25][CH:24]([NH:28][C:29]2[N:34]=[CH:33][C:32]([C:35]#[N:36])=[CH:31][CH:30]=2)[CH2:23]1>>[C:35]([C:32]1[CH:31]=[CH:30][C:29]([NH:28][CH:24]2[CH2:25][CH2:26][CH2:27][N:22]([C:2]3[C:7]([C:8]#[N:9])=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:4]([C:14]4[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=4)[N:3]=3)[CH2:23]2)=[N:34][CH:33]=1)#[N:36]

Participants

3

Reactant 2

HCID 670603386-(Piperidin-3-ylamino)nicotinonitrile hydrochlorideHCID 86656327HCID 86656327, compound

Product 1

HCID 67331684HCID 67331684, compound

Procedure

Analogously to the preparation of Example 20, 60 mg (0.2 mmol) of 2-chloro-6-(4-fluorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile and 59.5 mg (0.24 mmol) of 6-(piperidin-3-ylamino)pyridine-3-carbonitrile hydrochloride (Example 10A) were used to obtain, after separation by means of preparative HPLC (method 13), 61 mg (66% of theory) of the product in solid form.

Workup

  1. customto obtain
  2. customafter separation by means of preparative HPLC (method 13), 61 mg (66% of theory) of the product in solid form

Sources & evidence

ORD record
ord-c8b4ab2a791c4d2cb1ef2945d6b420d6
Source dataset
uspto-grants-2014_03
Patent number
US08664246B2

Reaction notes

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