HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-(4-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile → HCID 44625508, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-(4-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile | HCID 1477190 | — |
| Reactant | 6-(Piperidin-3-ylamino)nicotinonitrile hydrochloride | HCID 67060338 | — |
| Product | HCID 44625508 | HCID 44625508 | — |
Reaction Steps
Analogously to the preparation of Example 20, 60 mg (0.19 mmol) of 2-chloro-6-(4-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile and 56 mg (0.23 mmol) of 6-(piperidin-3-ylamino)pyridine-3-carbonitrile hydrochloride (Example 10A) were used to obtain, after separation by means of preparative HPLC (method 13), 46 mg (50% of theory) of the product in solid form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664246B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-49383c08d9e248bfb949e59587afbb24 |
| Source note | uspto-grants-2014_03 |