反应详情

A solution of 2-tert-butoxycarbonylamino-5-(4-methoxy-phenyl)-pentanoic acid methyl ester (5.6 g, 16.6 mmol) in MeOH (100 mL) is treated with aqueous ammonia solution (100 mL of a 28% solution in water, 28 mmol) and stirred at RT overnight. The organic solvent is removed in vacuo and the remaining aqueous portion is extracted with EtOAc (×3). The combined organic extracts are washed with brine and then dried (MgSO4) and concentrated in vacuo to afford the title compound as a yellow oil.

1. customThe organic solvent is removed in vacuo
2. extractionthe remaining aqueous portion is extracted with EtOAc (×3)
3. washThe combined organic extracts are washed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo