Potassium Carbonate → HCID 66917027, compound

Participants

Reaction Steps

To 3-(4-hydroxyphenyl)-1-propanol (10.0 g, 66.0 mmol) and potassium carbonate (13.5 g, 100 mmol) in acetone (200 mL) is added (S)-glycidol (6.5 mL, 100 mmol). The mixture is heated at reflux for 18 h. After cooling to RT the solvent is removed in vacuo and the residue partitioned between EtOAc and water. The aqueous layer is further extracted twice with EtOAc and the combined organic portions are washed with water, brine, then dried (MgSO4), filtered and concentrated in vacuo. The crude residue is purified by flash chromatography (SiO2, EtOAc:iso-hexane, 1:1) to afford the title compound as a white solid.

Provenance & Evidence