Phosphoric Acid → HCID 86649394, compound

Participants

Reaction Conditions

Reaction Steps

85% phosphoric acid aqueous solution (0.34 ml) was added to an ethanol solution (19 ml) of 1,3,3,5-Tetramethyl-7-(3-{[2-(1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]pyridin-4-ylmethylamino}-propoxy)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione (1.05 g, 1.84 mmol), and stirred at 50° C. for 15 minutes. The reaction mixture was cooled to room temperature. The precipitated insoluble matter was collected by filtration, washed with ethanol, and dried to thereby obtain 1.59 g (yield: 73%) of 1,3,3,5-Tetramethyl-7-(3-{[2-(1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]pyridin-4-ylmethylamino}-propoxy)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione tris(phosphate) as a white solid.

Provenance & Evidence