O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 178424252, compound

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Reaction Steps

0.45 mmol of 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid were dissolved in 5 ml of DMF, 0.54 mmol of TOTU and 1.125 mmol of NEM were added, and the mixture was stirred for 5 min at room temperature. Then 0.495 mmol of (S)-3-amino-3-o-tolyl-propionic acid were added and the mixture stirred overnight at room temperature. The solvent was evaporated in vacuo and the residue subjected to preparative HPLC to give the title compound in a yield of 28%.

Provenance & Evidence