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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1183168Generated: November 2, 2026

Cesium carbonate → HCID 67362940, compound

https://huagongshe.com/reaction/1183168

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCesium carbonateHCID 10796—
ReactantBromomethylcyclopropaneHCID 81503—
ReactantHCID 178498589HCID 178498589—
SolventTetrahydrofuranHCID 8028—
ProductHCID 67362940HCID 67362940—

Reaction Conditions

Temperature50 °C

Reaction Steps

150 mg (0.635 mmol) of methyl 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylate were dissolved in 8 ml of THF. 207 mg (0.635 mmol) of cesium carbonate and 400 mg (2.96 mmol) of bromomethyl-cyclopropane were added and the mixture was heated to 50° C. for 6 h. Then the mixture was filtrated and the solvent removed in vacuo. The crude title compound was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08664257B2
Source datasetuspto-grants-2014_03
ORD IDord-8004d0099c434602b8c3a369ab9f6efc
Source noteuspto-grants-2014_03