Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | HCID 178498589 | HCID 178498589 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67362940 | HCID 67362940 | — |
Reaction Steps
150 mg (0.635 mmol) of methyl 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylate were dissolved in 8 ml of THF. 207 mg (0.635 mmol) of cesium carbonate and 400 mg (2.96 mmol) of bromomethyl-cyclopropane were added and the mixture was heated to 50° C. for 6 h. Then the mixture was filtrated and the solvent removed in vacuo. The crude title compound was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08664257B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-8004d0099c434602b8c3a369ab9f6efc |
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| Source note | uspto-grants-2014_03 |
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