Bromine → HCID 67363138, compound

HRID 1183181Notes

Reaction equation

HRID 1183181 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([O:13][CH3:14])=[CH:11][C:10]([C:15]([OH:17])=[O:16])=[N:9]1.C([O-])(=O)C.[Na+].[Br:23]Br>C(O)(=O)C>[Br:23][C:11]1[C:10]([C:15]([OH:17])=[O:16])=[N:9][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[C:12]=1[O:13][CH3:14]

Participants

5

Reactant 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 67361662HCID 67361662, compound

Product 1

HCID 67363138HCID 67363138, compoundYield 90.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

50 mg (0.21 mmol) of 1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid were dissolved in 1.5 ml of acetic acid, sodium acetate (35 mg, 0.42 mmol) and bromine (50 mg, 0.21 mmol) were added and the mixture was stirred for 60 min. The solvent was removed in vacuo and the residue subjected to an aqueous work-up. The obtained crude title compound (60 mg) was used in the next step without further purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-b29864a4722341578028d74bfd8c71b0
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

Loading…