Sulfuryl chloride → HCID 67361928, compound

HRID 1183182Notes

Reaction equation

HRID 1183182 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[N:6]=1)=[O:4].S(Cl)([Cl:22])(=O)=O>C(O)(=O)C>[CH3:1][O:2][C:3]([C:5]1[C:9]([Cl:22])=[C:8]([O:10][CH3:11])[N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 67363124HCID 67363124, compound

Product 1

HCID 67361928HCID 67361928, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

300 mg (1.2 mmol) of 1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester was dissolved in 3 ml of acetic acid. 162 mg (1.2 mmol) of sulfuryl chloride were added and the mixture stirred for 4 h at room temperature. The solvent was removed in vacuo and the residue subjected to acidic aqueous work-up. The obtained crude title compound (330 mg) was used in the hydrolysis step without further purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-11566f3b6b4e45a6bc447bc95b335b16
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

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