Cesium carbonate → HCID 67362631, compound

Participants

Reaction Conditions

Reaction Steps

200 mg (0.85 mmol) of 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid methyl ester were dissolved in 5 ml of DMF. 552 mg (1.7 mmol) of cesium carbonate and 152 mg (0.85 mmol) of 1-bromo-3,3-dimethyl-butan-2-one were added and the mixture was heated to 50° C. for 6 h. Then the mixture was filtered and the solvent removed in vacuo. The obtained crude title compound was subjected to hydrolysis without further purification.

Provenance & Evidence