O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 67362073, compound

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Reaction Steps

324 mg (0.675 mmol) of 5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carboxylic acid were dissolved in 5 ml of DMF and 0.675 mmol of TOTU and 1.35 mmol of EDIA were added. The mixture was stirred for 5 min at room temperature, then 0.675 mmol of (S)-3-amino-3-(2-methyl-phenyl)-propionic acid were added and the mixture was stirred overnight at room temperature. After evaporation of the solvent, the residue was subjected to preparative HPLC to give the title compound in a yield of 67%.

Provenance & Evidence