HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 67495467, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 178419348 | HCID 178419348 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67495467 | HCID 67495467 | — |
Reaction Steps
To a solution of 4-(4-bromophenyl)-2-cyclopropyl-1H-imidazole (2.43 g, 9.23 mmol) and cesium carbonate (6.02 g, 18.47 mmol) in THF (30 mL) was added iodomethane (1.27 mL, 20.31 mmol). The reaction was stirred at rt for 19 hours. Water was added and the mixture was extracted with ethyl acetate. The organics were dried (MgSO4) and concentrated to afford the title compound which was used without further purification. LCMS: [M+1]+=277.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664253B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-9d97d0eb6ef44ae8a984a374edca092e |
| Source note | uspto-grants-2014_03 |