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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1183202Generated: October 31, 2026

Water → HCID 67495467, compound

https://huagongshe.com/reaction/1183202

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantMethyl iodideHCID 6328—
ReactantCesium carbonateHCID 10796—
ReactantHCID 178419348HCID 178419348—
SolventTetrahydrofuranHCID 8028—
ProductHCID 67495467HCID 67495467—

Reaction Steps

To a solution of 4-(4-bromophenyl)-2-cyclopropyl-1H-imidazole (2.43 g, 9.23 mmol) and cesium carbonate (6.02 g, 18.47 mmol) in THF (30 mL) was added iodomethane (1.27 mL, 20.31 mmol). The reaction was stirred at rt for 19 hours. Water was added and the mixture was extracted with ethyl acetate. The organics were dried (MgSO4) and concentrated to afford the title compound which was used without further purification. LCMS: [M+1]+=277.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08664253B2
Source datasetuspto-grants-2014_03
ORD IDord-9d97d0eb6ef44ae8a984a374edca092e
Source noteuspto-grants-2014_03