HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1183261Generated: October 25, 2026
Water → 1-{4'-[4-(2-Benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid
https://huagongshe.com/reaction/1183261
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-{4'-[4-(2-Benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester | HCID 66577705 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-{4'-[4-(2-Benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid | HCID 51347417 | — |
Reaction Steps
To 1-{4′-[4-(2-benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester (0.130 g, 0.24 mmol) in 2:1:1 THF:H2O:MeOH was added lithium hydroxide (0.050 g, 1.19 mmol), and the reaction was stirred at 70° C. for 2 hours. After acidic workup, the crude material was purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08664220B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-f9296dd3ffd14f94b40390b63bb380f9 |
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| Source note | uspto-grants-2014_03 |
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