Sodium Bicarbonate → HCID 66579429, compound

Participants

Reaction Conditions

Reaction Steps

[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-(4-o-tolyl-piperazin-1-yl)-methanone (0.156 g, 0.36 mmol), 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester (0.168 g, 0.53 mmol), tetrakis(triphenylphosphine)palladium(0) (0.042 g, 0.04 mmol), and sodium bicarbonate (0.076 g, 0.90 mmol) were combined in 3:1 DME:H2O, and the mixture was purged with N2 (g). The reaction was stirred at 80° C. for 1 hour and then cooled and concentrated. The crude material was purified by silica gel chromatography (0-40% EtOAc in hexanes) to give the title compound.

Provenance & Evidence