HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl morpholine oxide → 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl morpholine oxide | HCID 82029 | — |
| Reactant | [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol | HCID 58218538 | — |
| Catalyst | HCID 178419074 | HCID 178419074 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde | HCID 82133792 | — |
Reaction Steps
[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol (1.2 g, 4.5 mmol) was treated with 4-methylmorpholine N-oxide (0.786 g, 6.7 mmol) and tetrapropylammonium perruthenate (catalytic) in CH2Cl2. The reaction was monitored by analytical LCMS and when complete it was filtered through Celite then submitted to silica gel chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664220B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-f93e1b73f3db4e78b7204b52935873f6 |
| Source note | uspto-grants-2014_03 |