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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1183277Generated: November 1, 2026

Potassium Cyanide → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetonitrile

https://huagongshe.com/reaction/1183277

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CyanideHCID 9032—
Reactant4-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazoleHCID 66577223—
SolventDimethylformamideHCID 6228—
Product[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetonitrileHCID 66577425—

Reaction Conditions

Temperature65 °C

Reaction Steps

To 4-bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole (10.74 mmol) in DMF (30 mL) was added potassium cyanide (0.729 g, 10.74 mmol), and the reaction was stirred at 65° C. overnight. After aqueous workup, the crude material was purified by silica gel chromatography (0-70% EtOAc in hexanes) to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08664220B2
Source datasetuspto-grants-2014_03
ORD IDord-ef12515f12994659a3a659ffea52c7e6
Source noteuspto-grants-2014_03