Hydrazine → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid hydrazide

Participants

Role	Name	HCID	Charge
Reactant	Hydrazine	HCID 9321	—
Reactant	[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetic acid ethyl ester	HCID 66577263	—
Solvent	Ethanol	HCID 702	—
Solvent	Sodium chloride; water	HCID 57417360	—
Product	[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid hydrazide	HCID 66577599	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

To [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid ethyl ester (0.114 g, 0.37 mmol) in EtOH (4 mL) was added hydrazine (1M in THF; 2 mL), and the reaction was sealed and stirred at 80° C. overnight. The mixture was poured into brine and extracted with EtOAc. The combined organic layers were washed with H2O and brine, and then dried over MgSO4, filtered, and concentrated to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08664220B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-a6bad6fec8af4b348d842d8d5eadd162
Source note	uspto-grants-2014_03