Potassium tert-butoxide → HCID 66577678, compound

Participants

Reaction Conditions

Reaction Steps

Potassium tert-butoxide (1.0M in THF, 13.53 mL, 13.53 mmol) was added to a suspension of methyltriphenylphosphonium bromide (4.8 g, 13.53 mmol) in THF (40 mL) at 0° C. 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde (1.8 g, 6.76 mmol) in THF (40 mL) was then added and the reaction stirred at 0° C. for 30 minutes. The reaction was then submitted to standard aqueous workup and purified on silica gel to afford the title compound.

Provenance & Evidence