HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid ethyl ester | HCID 66577614 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid | HCID 66577681 | — |
Reaction Steps
2-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid ethyl ester (more polar isomer, 0.164 g, 0.468 mmol) was dissolved in THF (3 mL) then MeOH (1 mL) and NaOH (1N aq., 1 mL) were added. The reaction stirred at room temperature overnight and was then acidified with 1N aq. HCl and submitted to standard aqueous workup to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664220B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-5e29bff538bf44aca1114ad13fda0277 |
| Source note | uspto-grants-2014_03 |