(R)-(+)-N-Methyl-1-phenylethylamine → 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid methyl-((R)-1-phenyl-ethyl)-amide

HRID 1183312Notes

Reaction equation

HRID 1183312 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]2[CH2:16][CH:15]2[C:17]([OH:19])=O)=[CH:4][CH:3]=1.[CH3:20][NH:21][C@@H:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH3:23]>>[CH3:20][N:21]([C@@H:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH3:23])[C:17]([CH:15]1[CH2:16][CH:14]1[C:9]1[C:10]([CH3:13])=[N:11][O:12][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)=[O:19]

Participants

3

Reactant 2

HCID 2060888(R)-(+)-N-Methyl-1-phenylethylamineHCID 665776812-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid

Product 1

HCID 665776822-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid methyl-((R)-1-phenyl-ethyl)-amide

Procedure

Prepared according to the procedure described in Example 2, Step 1, using 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-cyclopropanecarboxylic acid and methyl-((R)-1-phenyl-ethyl)-amine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b246857d6eb64893843effbb468944c0
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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