5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]but-3-en-1-ol

HRID 1183323Notes

Reaction equation

HRID 1183323 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.[CH2:16]([Mg]Br)[CH:17]=[CH2:18]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:15])[CH2:18][CH:17]=[CH2:16])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehydeHCID 178455850HCID 178455850, compound

Product 1

HCID 665813481-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]but-3-en-1-ol

Procedure

Prepared according to the procedure described in Example 25, Step 1, using 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde and allyl magnesium bromide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-686caeb4bc8a43a6b65e93095fea4672
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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