참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate | HCID 53216840 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (1-(4-Bromophenyl)cyclopropyl)methanol | HCID 20252945 | — |
반응 단계
1-(4-Bromo-phenyl)-cyclopropanecarboxylic acid ethyl ester (25 g, 92.89 mmol) was dissolved in THF (175 mL) and was stirred under N2 atmosphere at −4° C. Lithium aluminum hydride (4.58 g, 120.75 mmol) was added in portions and the reaction stirred between 2 to 8° C. for 1 hour. The reaction was worked up using the Fieser method, filtered and concentrated to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08664220B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_03 |
|---|
| ORD ID | ord-fecfc81d224145bf9ae1a2c6fca16322 |
|---|
| 출처 메모 | uspto-grants-2014_03 |
|---|
