Trimethylsilylacetylene → HCID 66577713, compound

Participants

Reaction Steps

(Trimethylsilyl)acetylene (0.6926 mL, 5 mmol) and diethylzinc (1.1M in toluene, 4.54 mL, 5 mmol) were dissolved in toluene (15.5 mL) and stirred for 1 hour at room temperature. Then, N-[1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-meth-(E)-ylidene]-methanesulfonamide (1 g, 0.291 mmol) was added and the reaction was heated to 60° C. for 20 hours. The reaction was quenched with H2O and submitted to aqueous workup then purified via silica gel chromatography to yield the title compound which was brought directly to the next step.

Provenance & Evidence