Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → HCID 66579288, compound

HRID 1183360Notes

Reaction equation

HRID 1183360 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([CH:13]([C:19]2[C:20]([CH3:31])=[N:21][O:22][C:23]=2[C:24]2[CH:29]=[CH:28][C:27](Br)=[CH:26][CH:25]=2)[NH:14][S:15]([CH3:18])(=[O:17])=[O:16])[N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:32]([O:34][C:35]([C:37]1([C:40]2[CH:45]=[CH:44][C:43](B3OC(C)(C)C(C)(C)O3)=[CH:42][CH:41]=2)[CH2:39][CH2:38]1)=[O:36])[CH3:33]>>[CH2:32]([O:34][C:35]([C:37]1([C:40]2[CH:45]=[CH:44][C:43]([C:27]3[CH:28]=[CH:29][C:24]([C:23]4[O:22][N:21]=[C:20]([CH3:31])[C:19]=4[CH:13]([C:11]4[N:10]=[N:9][N:8]([CH2:1][C:2]5[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=5)[CH:12]=4)[NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:25][CH:26]=3)=[CH:42][CH:41]=2)[CH2:38][CH2:39]1)=[O:36])[CH3:33]

Participants

3

Reactant 2

HCID 53217182Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 66579383HCID 66579383, compound

Product 1

HCID 66579288HCID 66579288, compound

Procedure

Prepared according to the procedure described in Example 42, Step 2, using N-{(1-benzyl-1H-[1,2,3]triazol-4-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methyl}-methanesulfonamide and 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-cb1bd290185e499ea6757d801d93fb95
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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