5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde → (4-Benzyloxy-phenyl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

HRID 1183369Notes

Reaction equation

HRID 1183369 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.[CH2:16]([O:23][C:24]1[CH:29]=[CH:28][C:27]([Mg]Br)=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([O:23][C:24]1[CH:29]=[CH:28][C:27]([CH:14]([C:9]2[C:10]([CH3:13])=[N:11][O:12][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)[OH:15])=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehydeHCID 178419638HCID 178419638, compound

Product 1

HCID 66577612(4-Benzyloxy-phenyl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Procedure

Prepared according to the procedure described in Example 25, Step 1, using 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde and 4-(benzyloxy)phenyl magnesium bromide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-145cf22c31b342e9a9e6ff2504f22eee
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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