trans-2-Phenylcyclopropanecarboxylic acid → Ethanone, 1-[(1R,2R)-2-phenylcyclopropyl]-, rel- (9CI)

Participants

Reaction Conditions

Reaction Steps

trans-2-Phenyl-1-cyclopropanecarboxylic acid (2.0 g, 12.3 mmol) was dissolved in diethyl ether (40 mL) and cooled to 0° C. Methyllithium (1.6 M in hexanes, 16.8 mL, 27 mmol) was added dropwise and then the reaction stirred for 1 hour. The reaction was quenched with MeOH then submitted to standard aqueous workup and silica gel chromatography (0-40% EtOAc in hexanes) to afford the title compound.

Provenance & Evidence