Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 2,6-Dibromopyridine | HCID 12274 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Bromo-6-phenoxypyridine | HCID 824589 | — |
Reaction Steps
2,6-Dibromo-pyridine (2 g, 8.44 mmol) and phenol (0.794 g, 8.44 mmol) were dissolved in DMSO (20 mL) and potassium tert-butoxide (0.947 g, 8.44 mmol) was added. The reaction was heated to 160° C. overnight then allowed to cool to room temperature. The reaction was submitted to aqueous workup and silica gel chromatography to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08664220B2 |
|---|
| Source dataset | uspto-grants-2014_03 |
|---|
| ORD ID | ord-bfe40919a67f45a39a9a6a44f42e9d2d |
|---|
| Source note | uspto-grants-2014_03 |
|---|
