4-(2-Ethoxycarbonylethyl)benzeneboronic acid → 3-{4'-[3-Methyl-4-(5-phenyl[1,3,4]oxadiazol-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-propionic acid ethyl ester

HRID 1183415노트

반응식

HRID 1183415 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[NH:14][C:15]2[O:16][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:18][N:19]=2)=[CH:4][CH:3]=1.[CH2:26]([O:28][C:29]([CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=1)=[O:30])[CH3:27]>>[CH2:26]([O:28][C:29](=[O:30])[CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][C:36]([C:2]2[CH:3]=[CH:4][C:5]([C:8]3[O:12][N:11]=[C:10]([CH3:13])[C:9]=3[NH:14][C:15]3[O:16][C:17]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)=[N:18][N:19]=3)=[CH:6][CH:7]=2)=[CH:35][CH:34]=1)[CH3:27]

참가 물질

3

반응물 2

HCID 38517004-(2-Ethoxycarbonylethyl)benzeneboronic acidHCID 66577739[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-(5-phenyl-[1,3,4]oxadiazol-2-yl)-amine

생성물 1

HCID 665793373-{4'-[3-Methyl-4-(5-phenyl[1,3,4]oxadiazol-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-propionic acid ethyl ester

실험 절차

Prepared according to the procedure described in Example 42, Step 2, using [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-(5-phenyl-[1,3,4]oxadiazol-2-yl)-amine and [4-(2-ethoxycarbonylethyl)phenyl]boronic acid.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-5c4ecf5d5a7b4a73a6a220bf47f60b62
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08664220B2

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