1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester → HCID 66577747, compound

HRID 1183430Notes

Reaction equation

HRID 1183430 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH2:27])=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Br[C:29]1[CH:30]=[C:31]([C:35]2[C:36]([O:41][CH3:42])=[N:37][CH:38]=[CH:39][CH:40]=2)[CH:32]=[CH:33][CH:34]=1>>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH:27][C:33]4[CH:34]=[CH:29][CH:30]=[C:31]([C:35]5[C:36]([O:41][CH3:42])=[N:37][CH:38]=[CH:39][CH:40]=5)[CH:32]=4)=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 665771951-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl esterHCID 66577732HCID 66577732, compound

Product 1

HCID 66577747HCID 66577747, compound

Procedure

Prepared according to the procedure described in Example 68, Step 2, using 1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and 3-(3-bromo-phenyl)-2-methoxy-pyridine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b46efff28f1246dc98c9a171558398ed
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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