5-Methoxypyridine-3-boronic Acid → HCID 66577819, compound

HRID 1183445Notes

Reaction equation

HRID 1183445 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH:27][C:28]4[CH:33]=[CH:32][CH:31]=[C:30](Br)[CH:29]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:35][O:36][C:37]1[CH:38]=[C:39](B(O)O)[CH:40]=[N:41][CH:42]=1>>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH:27][C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([C:39]5[CH:40]=[N:41][CH:42]=[C:37]([O:36][CH3:35])[CH:38]=5)[CH:29]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27630875-Methoxypyridine-3-boronic AcidHCID 66577668HCID 66577668, compound

Product 1

HCID 66577819HCID 66577819, compound

Procedure

Prepared according to the procedure described in Example 1, Step 10, using 1-{4′-[4-(3-bromo-phenylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester and 5-methoxypyridine-3-boronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2cf368feb27d4990b97c10691751480e
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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