HRID1183469

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734345

{2-[(Dimethylamino)methyl]phenyl}boronic acid

C9H14BNO2

结构：CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(=O)c4cccc(Br)c4)cc3)cc2)CC1

HCID66577781

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(=O)c4cccc(-c5ccccc5CN(C)C)c4)cc3)cc2)CC1

HCID66577687

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure described in Example 1, Step 10, using 1-{4′-[4-(3-bromo-benzoylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester and 2-(N,N-dimethylaminomethyl)-phenylboronic acid.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fb55d4c800c64581bbdf0127377416de
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08664220B2
来源说明: uspto-grants-2014_03

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH:27][C:28](=[O:36])[C:29]4[CH:34]=[CH:33][CH:32]=[C:31](Br)[CH:30]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:37][N:38]([CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1B(O)O)[CH3:39]>>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH:27][C:28]([C:29]4[CH:30]=[C:31]([C:42]5[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=5[CH2:40][N:38]([CH3:39])[CH3:37])[CH:32]=[CH:33][CH:34]=4)=[O:36])=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]