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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1183472Generated: October 25, 2026

2-Bromo-6-(1H-pyrazol-1-yl)pyridine → 1-{4'-[3-Methyl-4-(6-pyrazol-1-yl-pyridin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/1183472

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-6-(1H-pyrazol-1-yl)pyridineHCID 7060529—
Reactant1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl esterHCID 66577195—
Product1-{4'-[3-Methyl-4-(6-pyrazol-1-yl-pyridin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl esterHCID 66579705—

Reaction Steps

Prepared according to the procedure described in Example 68, Step 2, using 1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and 2-bromo-6-pyrazol-1-yl-pyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08664220B2
Source datasetuspto-grants-2014_03
ORD IDord-d5562e619d904607a801d8a0ff2c0f7a
Source noteuspto-grants-2014_03