3,5-Dibromopyridine → 3-Bromo-5-(2-chloro-3-fluorophenyl)pyridine

HRID 1183516Notes

Reaction equation

HRID 1183516 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[Cl:9][C:10]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=1B(O)O>>[Br:8][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([C:11]2[CH:12]=[CH:13][CH:14]=[C:15]([F:16])[C:10]=2[Cl:9])[CH:7]=1

Participants

3

Reactant 2

HCID 693693,5-DibromopyridineHCID 22309459(2-Chloro-3-fluorophenyl)boronic acid

Product 1

HCID 665777773-Bromo-5-(2-chloro-3-fluorophenyl)pyridine

Procedure

Prepared according to the procedure described in Example 42, Step 2, using 3,5-dibromo-pyridine and 2-chloro-3-fluoro-phenylboronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d2e02f795042490eb18083217fa141b7
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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